ABCG1 Antibody (Center)
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Catalog number6705-100
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PricePlease ask
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Size100 μl
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Antibody TargetABCG1
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Target Alternative NameABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog
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Antibody TypePolyclonal
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Species ReactivitiesHuman
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Immunogen SequenceThis ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-387 amino acids from the central region of human ABCG1.
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AccessionP45844
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Gene IdABCG1
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AppearanceColorless liquid
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FormLiquid
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Formulation100 µl of antibody in PBS with 0.09% (W/V) sodium azide
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PurificationThis antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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ApplicationWestern blot, IHC, FACS
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Positive ControlWestern blot: 293 cell lysate, IHC: human hepatocarcinoma, FACS: HepG2 cells
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Application And UsagesWestern blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:50-1:100.
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DescriptionABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 is involved in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedVerified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedVerified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolABCG1
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Short nameABCG1 Antibody (Center)
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameadenosine triphosphate-binding cassette, sub-family G (WHITE), member 1 (antibody to-) (central)
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Alternative techniqueantibodies
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Alternative to gene targetATP-binding cassette, sub-family G (WHITE), member 1, ABC8 and WHITE1, ABCG1 and IDBG-4231 and ENSG00000160179 and 9619, protein dimerization activity, Cell surfaces, Abcg1 and IDBG-163644 and ENSMUSG00000024030 and 11307, BT.29337 and IDBG-639382 and ENSBTAG00000021272 and 510745
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Gene info
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Identity
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Gene
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Long gene nameATP binding cassette subfamily G member 1
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Synonyms gene name
- ATP-binding cassette, sub-family G (WHITE), member 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-10-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ATP binding cassette subfamily G
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data