CDK5RAP2 Antibody

• Catalog number
  bs-9076R
• Price
  Please ask
• Size
  0.1ml

• Long name
  CDK5RAP2 Primary Polyclonal Antibody
• Also known as
  CDK5RAP2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CDK5RAP2
• Specificity
  This is a highly specific antibody against CDK5RAP2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CDK5RAP2
• Gene ID number
  55755
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Cyclin dependent kinase 5 (Cdk5) is a key regulator of cell cycle progression in neuronal differentiation that physically associates with and is activated by the neuron-specific protein p35. CDK5RAP1 (CDK5 regulatory subunit-associated protein 1) specifically inhibits Cdk5 activation by p35 through formation of a dimer that inhibits kinase activity. CDK5RAP2, also known as Centrosome-associated protein 215, is a 1893 amino acid centrosomal protein that regulates activity of CDK5 through complex formation with CDK5RAP1. Expressed in placenta, liver, pancreas, heart, skeletal muscle, lung, brain and kidney, CDK5RAP2 associates with centrosomes throughout the cell cycle. Mutations in the gene encoding CDK5RAP2 results in primary microencephaly autosomal recessive type 3, which is characterized by markedly reduced head size, brain weight and significant neurological deficits. There are four isoforms of CDK5RAP2 that are produced as a result of alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  C48; CDK5 activator-binding protein C48; CDK5 regulatory subunit associated protein 2; CDK5 regulatory subunit-associated protein 2; centrosomal protein 215 kDa; Centrosome-associated protein 215; CEP215; MCPH3; CK5P2_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CDK5RAP2  
• Gene symbol
  CDK5RAP2
• Short name
  Anti-CDK5RAP2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  CDK5RAP2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:18672
• Gene
  CDK5RAP2
• Long gene name
  CDK5 regulatory subunit associated protein 2
• Synonyms gene
  • MCPH3
• Synonyms gene name
  • microcephaly, primary autosomal recessive 3
• Synonyms
  • C48
  • FLJ10867
  • CEP215
• Synonyms name
  • centrosomin
• GenBank acession
  • BK005504
• Locus
  9q33.2
• Discovery year
  2002-07-22
• Entrez gene record
  55755
• Pubmed identfication
  • 10721722
  • 17764569
  • 24466316
• RefSeq identity
  • NM_018249
• VEGA ID
  OTTHUMG00000021043

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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