MK-0941

Alternative_name

3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide
Description

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows decrease in mean fasting plasma glucose in healthy participants by 30 mg/dL. It displays greater effect in type 2 diabetic patients by lowering the fasting plasma glucose by 100 mg/dL.
CAS Number

1137916-97-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₂₄N₄O₆S
Molecular Weight

460.5
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(> 5 mg/ml)
Handling

Protect from air and light
Tag Line

An allosteric glucokinase activator (GKA)
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

O=C(NC1=NN(C)C=C1)C2=CC(O[C@@H](C)CO)=CC(OC3=CC=C(S(=O)(CC)=O)N=C3)=C2
InChi

InChI=1S/C21H24N4O6S/c1-4-32(28,29)20-6-5-16(12-22-20)31-18-10-15(9-17(11-18)30-14(2)13-26)21(27)23-19-7-8-25(3)24-19/h5-12,14,26H,4,13H2,1-3H3,(H,23,24,27)/t14-/m0/s1
InChi Key

KJSGTWFWVTYPFZ-AWEZNQCLSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:7530
Gene

MVK
Long gene name

mevalonate kinase
Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
Synonyms
- LRBP
- MK
Synonyms name
- LH receptor mRNA-binding protein
- mevalonic aciduria
GenBank acession
- M88468
Locus

12q24.11
Discovery year

1992-10-06
Entrez gene record

4598
Pubmed identfication
- 1377680
RefSeq identity
- NM_000431
VEGA ID

OTTHUMG00000169256
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_156

Identity

HGNC:6888
Gene

MAPKAPK3
Long gene name

MAPK activated protein kinase 3
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
Synonyms
- 3pK
- MAPKAP3
- 3PK
- MK-3
- MK3
GenBank acession
- U43784
Locus

3p21.2
Discovery year

1999-03-26
Entrez gene record

7867
Pubmed identfication
- 8626550
- 8622688
RefSeq identity
- NM_004635
Classification
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000156850

Identity

HGNC:11529
Gene

EPCAM
Long gene name

epithelial cell adhesion molecule
Synonyms gene
- M4S1
- MIC18
- TACSTD1
Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
Synonyms
- Ly74
- TROP1
- GA733-2
- EGP34
- EGP40
- EGP-2
- KSA
- CD326
- Ep-CAM
- HEA125
- KS1/4
- MK-1
- MH99
- MOC31
- MOC-31
- 323/A3
- 17-1A
- TACST-1
- CO-17A
- ESA
- BerEp4
- Ber-Ep4
Synonyms name
- trophoblast cell surface antigen 1
GenBank acession
- M33011
Locus

2p21
Discovery year

1995-10-02
Entrez gene record

4072
Pubmed identfication
- 8382772
- 11306819
Classification
- MicroRNA protein coding host genes
- CD molecules
VEGA ID

OTTHUMG00000128853
Locus Specific Databases
- Global Variome shared LOVD
- LRG_215