BAY 57-1293

  • Catalog number
    2556-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    N-methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide
  • Description
    BAY 57-1293 is a potent helicase primase inhibitor. It inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. BAY 57-1293 has been shown to be a more effective agent than acyclovir (Cat. No. 2200) for treating Alzjeimer’s Disease (AD) by decreasing Aβ and P-tau formation.
  • CAS Number
    348086-71-5
  • Structure Available
    Y
  • Salt Form
    No
  • Molecular Formula
    C₁₈H₁₈N₄O₃S₂
  • Molecular Weight
    402.49
  • Cell Permeable
    Yes
  • Purity
    ≥95% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent helicase primase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    24 months
  • PubChem CID
    491941
  • SMILES
    CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N
  • InChi
    InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
  • InChi Key
    IVZKZONQVYTCKC-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
    BAY   57-1293  
  • Gene symbol
    IGHV3-57, IGLV6-57, RNU6-57P, MIR1293, CNPPD1, FBXO9, C10orf99, OR5B1P
  • Short name
    BAY 57-1293
  • Alternative name
    BAY 57-1293
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 3-57 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable 3-57
    • immunoglobulin heavy variable 3-57 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-04
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
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