anti-DIRAS3 Antibody

• Catalog number
  8139
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).
• Gene names
  DIRAS family GTP-binding RAS-like 3, ARHI, NOEY2
• Antibodie s label
  unlabelled serum
• Purity
  DIRAS3 antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  DIRAS3 antibody is human specific.
• Antigen
  DIRAS3 antibody was made against an 18 amino acid peptide near the carboxy terminus of human DIRAS3.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 ug/ml.
• Suspention pH azide
  DIRAS3 antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  DIRAS3 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human
• Omim nr
  4757772
• Ncbi nr
  NP_004666
• KDa
  Predicted: 25 kDa Observed: 24 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  9077
• GENE symbol
  DIRAS3
• Antigene name
  DIRAS family, GTP-binding RAS-like 3
• Source
  homo sapiens
• Protein nr
  O95661
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DIRAS3  
• Gene symbol
  DIRAS3
• Short name
  anti-DIRAS3 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toDIRAS3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:687
• Gene
  DIRAS3
• Long gene name
  DIRAS family GTPase 3
• Synonyms gene
  • ARHI
• Synonyms gene name
  • ras homolog gene family, member I
  • DIRAS family, GTP-binding RAS-like 3
• Synonyms
  • NOEY2
• Synonyms name
  • GTP-binding protein Di-Ras3
  • distinct subgroup of the Ras family member 3
• GenBank acession
  • U96750
• Locus
  1p31.3
• Discovery year
  1999-01-22
• Entrez gene record
  9077
• Pubmed identfication
  • 9874798
  • 12194967
  • 18302158
• RefSeq identity
  • NM_004675
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000009544
• Locus Specific Databases
  • LRG_1034

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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