PD-168393
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Catalog numberB2352-5
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PricePlease ask
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Size5 mg
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Alternative_namePD168393,N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propenamide
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DescriptionPD-168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 0.70 nM). PD-168393 decreases the production of TNF-α and phosphorylation of ERK1/2 and p38 induced by LPS in cardiomyocytes.
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CAS Number194423-15-9
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Structure AvailableYes
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Molecular FormulaC₁₇H₁₃BrN₄O
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Molecular Weight369.2
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Cell Permeable1
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Purity≥98% by HPLC
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Solubilities>25 mg/ml (DMSO) in 0
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HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag LineA potent, EGFR kinase inhibitor
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Storage Condition-20ºC
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Shipping ConditionGel Pack
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Shelf Life36 months
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MDL NumberMFCD02179207
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PubChem CID4708
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SMILESC=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
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InChiInChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
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InChi KeyHTUBKQUPEREOGA-UHFFFAOYSA-N
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MSDS Available1
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Gene target
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Gene symbolENPP2, PDCD1, ENPP3, PDCD1LG2, CD274, VSIR
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Short namePD-168393
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Alternative namePD-168393
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Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 2
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-08-10
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Entrez gene record
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Pubmed identfication
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogrammed cell death 1
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Synonyms gene
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Synonyms gene name
- systemic lupus erythematosus susceptibility 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-05-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 3
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-08-10
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Entrez gene record
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Pubmed identfication
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogrammed cell death 1 ligand 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCD274 molecule
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Synonyms gene
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Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameV-set immunoregulatory receptor
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Synonyms gene
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Synonyms gene name
- chromosome 10 open reading frame 54
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- V-set domain containing
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VEGA ID