Recombinant Human TNFRSF4 / OX40 / CD134 Protein (His & Fc tag)

  • Catalog number
    PKSH031578-50µg
  • Price
    Please ask
  • Size
    50µg
  • Synonym
    ACT35;CD134;IMD16;OX40;TXGP1L
  • Activity
    Immobilized Cynomolgus mFc-TNFSF4 at 10 μg/ml (100 μl/well) can bind human TNFRSF4-Fch, The EC50 of human TNFRSF4-Fch is 0.23-0.55 μg/ml.
  • Sequence
    Met 1-Ala 216
  • Fusion tag
    C-His & Fc
  • Accession
    NP_003318.1
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    >85 % as determined by SDS-PAGE
  • Endotoxin
    <1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    48.2 kDa
  • AP Mol Mass
    68 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.Immune CheckpointImmune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    TNFRSF4   OX40   CD134   Protein   His   tag  
  • Gene symbol
    TNFRSF4
  • Short name
    Recombinant TNFRSF4 / OX40 / CD134 Protein (His & Fc tag)
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    His
  • Species
    Human, Humans
  • Alternative name
    Rec. H. sapiens tumor necrosis factor receptor superfamily, member 4 / OX40 / CD134 Protein (histidine & fragment c detection labelled)
  • Alternative technique
    rec
  • Alternative to gene target
    tumor necrosis factor receptor superfamily, member 4, ACT35 and CD134 and IMD16 and OX40 and TXGP1L, TNFRSF4 and IDBG-84605 and ENSG00000186827 and 7293, protein binding, Cell surfaces, Tnfrsf4 and IDBG-208242 and ENSMUSG00000029075 and 22163, TNFRSF4 and IDBG-635323 and ENSBTAG00000015635 and 528782
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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