Human CellExp™ TNFRSF10A / TRAIL R1, human recombinant

  • Catalog number
    P1141-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    TNFRSF10A, TRAIL-R1, CD261, APO2, DR4
  • Alternative_names
    TNFRSF10A, TRAIL-R1, CD261, APO2, DR4
  • Description
    Receptor for the cytotoxic ligand TNFSF10/TRAIL
  • Recombinant
    Yes
  • Source
    HEK 293 cells
  • Purity by SDS PAGE
    > 95%
  • Assay
    SDS-PAGE
  • Endotoxin Level
    < 1.0 EU per/ug
  • Molecular Weight
    24 kDa
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
  • Reconstitution Instructions
    Reconstitute in sterile deionized water to the desired protein concentration.
  • Background Information
    Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    TNFRSF10A-DT, TNFRSF10A-AS1, TNFSF10, TNFRSF10A, TNFRSF10B
  • Short name
    CellExp™ TNFRSF10A / TRAIL R1, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ tumor necrosis factor receptor superfamily, member 10a / TRAIL R1, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    tumor necrosis factor receptor superfamily, member 10a, APO2 and CD261 and DR4 and TRAILR-1 and TRAILR1, TNFRSF10A and IDBG-11715 and ENSG00000104689 and 8797, TRAIL binding, Plasma membranes
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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