XRCC3 Antibody

• Catalog number
  R30783
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  XRCC3
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the XRCC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This XRCC3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9CXE6
• Purity
  Antigen affinity
• Description
  X-RAY repair, complementing defective, in chinese hamster, 3 is a DNA repair protein that in humans is encoded by the XRCC3 gene. It is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. XRCC3 function is not limited to HR initiation, but extends to later stages in formation and resolution of HR intermediates, possibly by stabilizing heteroduplex DNA. The gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
• Immunogen
  An amino acid sequence from the C-terminus of mouse XRCC3 (NQLLMRLMVDRTHEDD) was used as the immunogen for this XRCC3 antibody (100% rat homology).
• Storage
  After reconstitution, the XRCC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  XRCC3  
• Gene symbol
  XRCC3
• Short name
  Anti-XRCC3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to XRCC3
• Alternative technique
  antibodies
• Alternative to gene target
  X-ray repair complementing defective repair in Chinese hamster cells 3, CMM6, XRCC3 and IDBG-22058 and ENSG00000126215 and 7517, crossover junction endodeoxyribonuclease activity, nuclei, Xrcc3 and IDBG-173748 and ENSMUSG00000021287 and 74335, XRCC3 and IDBG-635474 and ENSBTAG00000009966 and 768244

Gene info

• Identity
  HGNC:12830
• Gene
  XRCC3
• Long gene name
  X-ray repair cross complementing 3
• Synonyms gene name
  • X-ray repair complementing defective repair in Chinese hamster cells 3
• Synonyms name
  • RAD51-like
• GenBank acession
  • AF035586
• Locus
  14q32.33
• Discovery year
  1995-08-11
• Entrez gene record
  7517
• Pubmed identfication
  • 7603995
• RefSeq identity
  • NM_005432
• VEGA ID
  OTTHUMG00000169228

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products