2-Methyl-5-hydroxytryptamine hydrochloride

Alternative_name

3-(2-aminoethyl)-2-methyl-1H-indol-5-ol hydrochloride; 2-Me-5HT
Description

2-Methyl-5-hydroxytryptamine is a 5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM). Recently, this has been used as one of the components of the chemical cocktails used for reprogramming of mouse somatic cells toward pluripotent cells in the absence of Oct4.
CAS Number

845861-49-6
Structure Available

Y
Salt Form

No
Molecular Formula

C₁₁H₁₄N₂O.HCl
Molecular Weight

226.71
Cell Permeable

Y
Purity

≥98% by HPLC
Solubilities

H₂O (>20 mg/ml)
Handling

Protect from light and moisture
Tag Line

A 5-HT3 agonist
Storage Condition

RT
Shipping Condition

RT
Shelf Life

36 months
PubChem CID

11492320
PubChem CID Link
SMILES

CC1=C(C2=C(N1)C=CC(=C2)O)CCN.Cl
InChi

InChI=1S/C11H14N2O.ClH/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7;/h2-3,6,13-14H,4-5,12H2,1H3;1H
InChi Key

ZNVRHQPXSBWLQP-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes
Additional description

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3. In formulas, the group is often abbreviated Me. Such hydrocarbon groups occur in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, it can be found on its own in any of three forms anion, cation or radical. The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed,

Gene target

2-Methyl-5-hydroxytryptamine hydrochloride
Gene symbol

MIR1302-5, PIRC22, PIRC23, PIRC20, PIRC21, HTR6, IGKV3OR2-5, IGHV2OR16-5, SNORD116-5, TGFB1I1
Short name

2-Methyl-5-hydroxytryptamine hydrochloride
Alternative name

2-Methyl-5-hydroxytryptamine hydrochloride

Identity

HGNC:5301
Gene

HTR6
Long gene name

5-hydroxytryptamine receptor 6
Synonyms gene name
- 5-hydroxytryptamine (serotonin) receptor 6
- 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Synonyms
- 5-HT6
- 5-HT6R
GenBank acession
- L41147
Locus

1p36.13
Discovery year

1997-12-11
Entrez gene record

3362
Pubmed identfication
- 8522988
RefSeq identity
- NM_000871
Classification
- 5-hydroxytryptamine receptors, G protein-coupled
VEGA ID

OTTHUMG00000002713

Identity

HGNC:5832
Gene

IGKV3OR2-5
Long gene name

immunoglobulin kappa variable 3/OR2-5 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 3/OR2-5
- immunoglobulin kappa variable 3/OR2-5 pseudogene
Synonyms
- IGKV3/OR2-5
GenBank acession
- X51882
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28854
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000184519