5HT2B Receptor/SR-2B Antibody

• Catalog number
  bs-12050R
• Price
  Please ask
• Size
  0.1ml

• Long name
  5HT2B Receptor/SR-2B Primary Polyclonal Antibody
• Also known as
  5HT2B Receptor/SR-2B PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  5HT2B Receptor/SR-2B
• Specificity
  This is a highly specific antibody against 5HT2B Receptor/SR-2B.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human 5HT2B Receptor/SR-2B
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  5 HT 2B; 5 HT 2B receptor; 5 HT2B; 5 HT2B; 5 hydroxytryptamine serotonin receptor 2B; 5 hydroxytryptamine serotonin receptor 2B G protein coupled; 5 hydroxytryptamine 2B receptor; 5 hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; 5-hydroxytryptamine receptor 2B; 5HT2B; 5HT2B_HUMAN; 5HT2F; Htr 2b; Htr2b; NP75 protein; SEROTONIN 5HT2B RECEPTOR; Serotonin receptor 2B; Stomach fundus serotonin receptor.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• French translation
  anticorps

• Gene target
  5HT2B   Receptor/SR-2B  
• Gene symbol
  IGHD2OR15-2B, MSR1, CXCL3, MEGF10, MARCO, EIF2B3, SRPRB, SIGMAR1, SNCG, SNORD3B-2
• Short name
  Anti-5HT2B Receptor/SR-2B
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  5HT2B Receptor/SR-2B Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:5494
• Gene
  IGHD2OR15-2B
• Long gene name
  immunoglobulin heavy diversity 2/OR15-2B (non-functional)
• Synonyms gene name
  • immunoglobulin heavy diversity 2/OR15-2B
• Synonyms
  • IGHD2/OR15-2B
  • IGHD2OR152B
• GenBank acession
  • X55578
• Locus
  15q11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28332
• Pubmed identfication
  • 2114977
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000184595

Gene info

• Identity
  HGNC:7376
• Gene
  MSR1
• Long gene name
  macrophage scavenger receptor 1
• Synonyms
  • SCARA1
  • CD204
  • SR-AI
  • SR-AII
  • SR-AIII
  • SR-A
• GenBank acession
  • D13263
• Locus
  8p22
• Discovery year
  1991-08-07
• Pubmed identfication
  • 2251254
• Classification
  • CD molecules
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000094809

Gene info

• Identity
  HGNC:4604
• Gene
  CXCL3
• Long gene name
  C-X-C motif chemokine ligand 3
• Synonyms gene
  • GRO3
• Synonyms gene name
  • GRO3 oncogene
  • chemokine (C-X-C motif) ligand 3
• Synonyms
  • SCYB3
  • GROg
  • MIP-2b
  • CINC-2b
• GenBank acession
  • M36821
• Locus
  4q13.3
• Discovery year
  1991-05-21
• Entrez gene record
  2921
• Pubmed identfication
  • 2217207
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000160861

Gene info

• Identity
  HGNC:29634
• Gene
  MEGF10
• Long gene name
  multiple EGF like domains 10
• Synonyms gene name
  • multiple EGF-like-domains 10
• Synonyms
  • KIAA1780
  • SR-F3
• GenBank acession
  • AK021631
• Locus
  5q23.2
• Discovery year
  2006-03-31
• Entrez gene record
  84466
• Pubmed identfication
  • 11347906
  • 27170117
• RefSeq identity
  • NM_032446
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000128984

Gene info

• Identity
  HGNC:6895
• Gene
  MARCO
• Long gene name
  macrophage receptor with collagenous structure
• Synonyms
  • SCARA2
  • SR-A6
• Synonyms name
  • scavenger receptor class A, member 2
• GenBank acession
  • AF035819
• Locus
  2q14.2
• Discovery year
  1998-11-26
• Entrez gene record
  8685
• Pubmed identfication
  • 9468508
  • 7867067
  • 10331948
• RefSeq identity
  • NM_006770
• Classification
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000131400

Gene info

• Identity
  HGNC:3259
• Gene
  EIF2B3
• Long gene name
  eukaryotic translation initiation factor 2B subunit gamma
• Synonyms gene name
  • eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD)
  • eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
• Synonyms
  • EIF2Bgamma
  • EIF-2B
• GenBank acession
  • AF257077
• Locus
  1p34.1
• Discovery year
  1998-10-16
• Entrez gene record
  8891
• Pubmed identfication
  • 10900014
• RefSeq identity
  • NM_020365
• VEGA ID
  OTTHUMG00000008585

Gene info

• Identity
  HGNC:24085
• Gene
  SRPRB
• Long gene name
  SRP receptor subunit beta
• Synonyms gene name
  • signal recognition particle receptor, B subunit
• Synonyms
  • APMCF1
  • SR-beta
• GenBank acession
  • AK075531
• Locus
  3q22.1
• Discovery year
  2004-01-29
• Entrez gene record
  58477
• Pubmed identfication
  • 7844142
  • 10859309
• VEGA ID
  OTTHUMG00000159753

Gene info

• Identity
  HGNC:8157
• Gene
  SIGMAR1
• Long gene name
  sigma non-opioid intracellular receptor 1
• Synonyms gene
  • OPRS1
• Synonyms gene name
  • opioid receptor, sigma 1
• Synonyms
  • SR-BP1
• GenBank acession
  • BC004899
• Locus
  9p13.3
• Discovery year
  1993-03-11
• Entrez gene record
  10280
• Pubmed identfication
  • 8954936
  • 9453537
• RefSeq identity
  • NM_005866
• VEGA ID
  OTTHUMG00000019829

Gene info

• Identity
  HGNC:11141
• Gene
  SNCG
• Long gene name
  synuclein gamma
• Synonyms
  • BCSG1
  • SR
  • persyn
• Synonyms name
  • synoretin
  • breast cancer-specific gene 1
  • ɣ-synuclein
• GenBank acession
  • AF044311
• Locus
  10q23.2
• Discovery year
  1998-04-07
• Entrez gene record
  6623
• Pubmed identfication
  • 9044857
  • 9700196
• VEGA ID
  OTTHUMG00000018656
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:33190
• Gene
  SNORD3B-2
• Long gene name
  small nucleolar RNA, C/D box 3B-2
• Synonyms
  • U3-2B
  • U3b2
• Synonyms name
  • U3 snoRNA B-2
  • U3 small nucleolar RNA B-2
• Locus
  17p11.2
• Discovery year
  2006-11-28
• Entrez gene record
  780852
• Pubmed identfication
  • 9365252
• RefSeq identity
  • NR_003924
• Classification
  • Small nucleolar RNAs, C/D box
• VEGA ID
  OTTHUMG00000178152

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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