Ro 61-8048
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Catalog number1912-25
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PricePlease ask
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Size25 mg
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Alternative_name3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
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DescriptionCell-permeable. A high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC₅₀ = 37 nM).
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CAS Number199666-03-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₅N₃O₆S₂
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Molecular Weight421.45
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (100 mM) or EtOH (10 mM)
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HandlingProtect from light
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Tag LineAn inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD11040807
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PubChem CID5282337
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SMILESCOC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC
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InChiInChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
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InChi KeyNDPBMCKQJOZAQX-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolIGHV4-61, SNORA81, IGLV8-61, RNU6-61P, SCARNA2, SH3GLB1
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Short nameRo 61-8048
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Alternative nameRo 61-8048
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Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 4-61
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, H/ACA box 81
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-04-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, H/ACA box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable 8-61
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 61, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 61
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Locus
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Discovery year2011-08-08
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Entrez gene record
Gene info
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Identity
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Gene
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Long gene namesmall Cajal body-specific RNA 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-03-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small Cajal body-specific RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSH3 domain containing GRB2 like, endophilin B1
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Synonyms gene name
- SH3-domain, GRB2-like, endophilin B1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-07-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- N-BAR domain containing
- Protein phosphatase 1 regulatory subunits
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VEGA ID