Lin-28 Antibody, ALEXA FLUOR 555

• Catalog number
  bs-6446R-A555
• Price
  Please ask
• Size
  100ul

• Long name
  Lin-28 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
• Also known as
  Anti-Lin-28 PAb ALEXA FLUOR 555
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 555
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Lin-28
• Specificity
  This is a highly specific antibody against Lin-28.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  70-120/250
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Lin-28B
• Gene ID Number
  389421, 79727
• Swiss Prot
  Q6ZN17,Q9H9Z2
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  553nm/568nm
• Synonyms
  Lin28B; CSDD 2; CSDD2; FLJ16517; Lin 28 homolog B C. elegans; Lin 28.2; Lin-28B; LIN28B; LN28B_HUMAN; Protein lin-28 homolog B; Protein lin-28 homolog A, Lin-28A, Zinc finger CCHC domain-containing protein 1.
• Properties
  For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 555
• French translation
  anticorps

• Gene target
  Lin-28  
• Gene symbol
  LIN28A, LIN28B, LIN28AP3
• Short name
  Anti-Lin-28
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 555
• Alternative name
  Lin-28 Polyclonal Antibody, ALEXA FLUOR 555
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15986
• Gene
  LIN28A
• Long gene name
  lin-28 homolog A
• Synonyms gene
  • LIN28
• Synonyms gene name
  • lin-28 homolog (C. elegans)
• Synonyms
  • LIN-28
  • FLJ12457
  • ZCCHC1
  • CSDD1
• GenBank acession
  • AF521099
• Locus
  1p36.11
• Discovery year
  2003-07-21
• Entrez gene record
  79727
• Pubmed identfication
  • 12798299
• RefSeq identity
  • NM_024674
• Classification
  • Zinc fingers CCHC-type
• VEGA ID
  OTTHUMG00000003550

Gene info

• Identity
  HGNC:32207
• Gene
  LIN28B
• Long gene name
  lin-28 homolog B
• Synonyms gene name
  • lin-28 homolog B (C. elegans)
• Synonyms
  • FLJ16517
  • CSDD2
• GenBank acession
  • AK131411
• Locus
  6q16.3-q21
• Discovery year
  2005-08-22
• Entrez gene record
  389421
• RefSeq identity
  • NM_001004317
• VEGA ID
  OTTHUMG00000015290

Gene info

• Identity
  HGNC:38057
• Gene
  LIN28AP3
• Long gene name
  LIN28A pseudogene 3
• Synonyms gene name
  • lin-28 homolog A (C. elegans) pseudogene 3
• Locus
  20p12.2
• Discovery year
  2010-04-06
• Entrez gene record
  441940

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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