Anti-TIM3 Antibody
-
Catalog numberA1390-100
-
PricePlease ask
-
Size100 µl
-
-
Antibody TargetTIM3
-
Target Alternative NameTIM3, TIMD3, Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3
-
Antibody TypePolyclonal
-
Species ReactivitiesHuman and Mouse
-
Immunogen SequenceKLH-conjugated synthetic peptide of human TIM3
-
AccessionQ8TDQ0
-
Gene Id84868
-
AppearanceColorless liquid
-
FormLiquid
-
FormulationIn 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
-
PurificationAffinity purified
-
ApplicationWestern blot, IHC
-
Positive ControlWB: HepG2, BT474, mouse lung, mouse thymus whole cell lysates; IHC: human breast cancer tissue
-
Application And UsagesWB; 1:500 – 1:1000; IHC: 1:50 – 1:200
-
DescriptionAs a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. It is known to synergize with Toll-like receptors and is thought to regulate Th1 and Th17 cytokine secretion.
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life12 months
-
UsageFor Research Use Only! Not to be used in humans.
-
HandlingThe antibody solution should be gently mixed before use.
-
Western Blot VerifiedVerified
-
Immunocytochemistry VerifiedVerified
-
Immunofluorescence VerifiedNot Verified
-
Immunoprecipitation VerifiedNot Verified
-
FACS VerifiedNot Verified
-
ELISA VerifiedNot Verified
-
ChIP VerifiedNot Verified
-
Dot Blot VerifiedNot Verified
-
Flow Cytometry VerifiedNot Verified
-
Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolHAVCR2
-
Short nameAnti-TIM3 Antibody
-
TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
IsotypeRabbit IgG
-
Alternative nameAntibody toTIM3 (antibody to-)
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namehepatitis A virus cellular receptor 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-12-04
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- V-set domain containing
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data