anti-CXXC4 Antibody

• Catalog number
  6041
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
• Gene names
  CXXC4 Antibody: IDAX, IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein
• Antibodie s label
  unlabelled serum
• Purity
  CXXC4 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  CXXC4 antibody was made against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  CXXC4 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  13376816
• Ncbi nr
  NP_079488
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  80319
• GENE symbol
  CXXC4
• Antigene name
  CXXC finger protein 4
• Source
  Homo sapiens
• Protein nr
  Q9H2H0
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CXXC4  
• Gene symbol
  CXXC4, CXXC4-AS1
• Short name
  anti-CXXC4 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCXXC4 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24593
• Gene
  CXXC4
• Long gene name
  CXXC finger protein 4
• Synonyms
  • IDAX
• Synonyms name
  • Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
• Locus
  4q24
• Discovery year
  2004-02-18
• Entrez gene record
  80319
• Pubmed identfication
  • 11113207
• RefSeq identity
  • NM_025212
• Classification
  • Zinc fingers CXXC-type
• VEGA ID
  OTTHUMG00000131121

Gene info

• Identity
  HGNC:41054
• Gene
  CXXC4-AS1
• Long gene name
  CXXC4 antisense RNA 1
• Locus
  4q24
• Discovery year
  2017-01-10
• Entrez gene record
  101929468
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000160977

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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