Piperlongumine, Apoptosis Inducer
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Catalog number
SIH-156-100MG
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Price
Please ask
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Size
100 mg
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Stock availabilitIn Stock
In Stock
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CAS number
20069-09-4
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Description
Apoptosis Inducer
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Molecular weight
317,3 g/mol
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Primary research fields
Cancer, Oxidative Stress
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Other name
1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C17H19NO5
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in 25 mg/ml DMSO
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Physical appearance
Cream Solid
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Storage recommendations
-20ÂșC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
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PubChem number
637858
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Scientific context
Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).
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Bibliography
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231.
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Release date
26-Aug-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol. Chemical structure of Piperlongumine, a Apoptosis inducer in oxidative stressed cells (SIH-156). CAS # 20069-09-4. Molecular Formula: C17H19NO5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.1
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Additional description
This 1 is suited for programmed cell-death studies.
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Gene target
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Short name
Piperlongumine, Apoptosis Inducer
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Technique
apoptosis, apoptosis pathway
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Alternative name
Piperlongumine, programmed cellular destruction Inducer
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Alternative technique
celldeath
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