UACA / Nucling (Nuclear Membrane Marker) Mouse Monoclonal Antibody

  • Catalog number
    MBS439068
  • Price
    Please ask
  • Size
    5x0.1 mg (Without BSA & Azide at 1mg/mL)
  • Products_type
    Antibody
  • Products_short_name
    [UACA / Nucling]
  • Products_name_syn
    [Nuclear membrane binding protein; Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA); NUCLING]
  • Other_names
    [uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2; Uveal autoantigen with coiled-coil domains and ankyrin repeats; uveal autoantigen with coiled-coil domains and ankyrin repeats; uveal autoantigen with coiled-coil domains and ankyrin repeats]
  • Products_gene_name
    [UACA]
  • Other_gene_names
    [UACA; UACA; NUCLING; KIAA1561]
  • Clonality
    Monoclonal
  • Clone
    [UACA/1222]
  • Reactivity
    Human, Mouse
  • Specificity
    UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
  • Form
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Storage_stability
    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Tested_application
    Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
  • Properties
    If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Description
    Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. 
  • About
    Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    UACA
  • Short name
    UACA / Nucling ( ) Mouse Monoclonal Antibody
  • Technique
    Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
  • Host
    Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
  • Isotype
    IgG1, kappa
  • Species
    Mouse, Mouses
  • Alternative name
    uveal autoantigen including coiled-coil domains and ankyrin repeats / Nucling (Nuclear Membrane detection labelled) Mouse monoclonal (antibody to-)
  • Alternative technique
    antibodies, murine
  • Alternative to gene target
    uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA and IDBG-19585 and ENSG00000137831 and 55075, protein binding, nuclei, Uaca and IDBG-173915 and ENSMUSG00000034485 and 72565, BT.26227 and IDBG-645550 and ENSBTAG00000013982 and 281559
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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