Actinomycin D (10 mM)
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Catalog number1036-50
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PricePlease ask
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Size50 ul
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Alternative_nameActinomycin C1, Actinomycin IV, Dactinomycin
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DescriptionAn antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines (1).
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CAS Number50-76-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₆₂H₈₆N₁₂O₁₆
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Molecular Weight1255.5
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Cell PermeableNo
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Purity>98% by TLC
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HandlingProtect from light and moisture
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Tag LineAn antineoplastic antibiotic
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life6 months
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MDL NumberMFCD00005033
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PubChem CID2019
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SMILESCC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O) C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O) C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
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InChiInChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25- 38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31 (9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89- 62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28 (3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2, 1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)
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InChi KeyRJURFGZVJUQBHK-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameActinomycin D (10 mM)
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Alternative nameActinomycin D (10 millimeter)
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