CRT Inhibitor, iCRT5

• Catalog number
  1896-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
• Description
  Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC₅₀ of 18 nM. It acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₆H₁₇NO₅S₂
• Molecular Weight
  367.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A β-catenin-responsive transcription (CRT) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  CRT   Inhibitor   iCRT5  
• Gene symbol
  CALR
• Short name
  CRT Inhibitor, iCRT5
• Alternative name
  CRT suppressor, iCRT5

Gene info

• Identity
  HGNC:1455
• Gene
  CALR
• Long gene name
  calreticulin
• Synonyms
  • RO
  • SSA
  • cC1qR
  • CRT
  • FLJ26680
• Synonyms name
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • autoantigen Ro
• GenBank acession
  • M84739
• Locus
  19p13.13
• Discovery year
  1990-09-10
• Entrez gene record
  811
• Pubmed identfication
  • 2365822
• RefSeq identity
  • NM_004343
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000180574
• Locus Specific Databases
  • LRG_828

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