anti-RET Antibody [6E4C4]

• Catalog number
  32-211
• Price
  Please ask
• Size
  0.1 mL

• Gene info
  RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung抯 disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
• Gene names
  CDHF12, CDHR16, PTC, RET51, Cadherin family member 12PTC, MTC1, HSCR1, MEN2A, MEN2B, CDHF12, RET-ELE1
• Antibodie s label
  unlabelled serum
• Ab raised in
  Mouse
• Type
  Monoclonal
• Monoclonal
  6E4C4
• Immunoglobulin
  IgG1
• Antigen
  Purified truncated recombinant RET (aa896-1063)-GST fusion protein is expressed in E. Coli strain BL21 (DE3)._x000D_
• Immuno application
  ELISA, Western Blot
• Antibody advice
  Western Blot:1:500 - 1:2,000 IHC(P):1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
• Suspention pH azide
  Ascitic fluid containing 0.03% sodium azide.
• Keep at
  RET monoclonal antibody can be stored at -20 grades C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  547807
• Ncbi nr
  P07949
• NCBI GENE nr
  5979
• GENE symbol
  RET
• Antigene name
  ret proto-oncogene
• Source
  Homo sapiens
• Protein nr
  P07949
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RET   [6E4C4]  
• Gene symbol
  GOLGA5, RET
• Short name
  anti-RET Antibody [6E4C4]
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toRET (antibody to-) [6E4C4]
• Alternative technique
  antibodies
• Alternative to gene target
  ret proto-oncogene, CDHF12 and CDHR16 and HSCR1 and MEN2A and MEN2B and MTC1 and PTC and RET-ELE1 and RET51, RET and IDBG-71064 and ENSG00000165731 and 5979, transferase activity, Plasma membranes, Ret and IDBG-181393 and ENSMUSG00000030110 and 19713, RET and IDBG-628722 and ENSBTAG00000000570 and 515924

Gene info

• Identity
  HGNC:4428
• Gene
  GOLGA5
• Long gene name
  golgin A5
• Synonyms gene name
  • golgi autoantigen, golgin subfamily a, 5
• Synonyms
  • ret-II
  • golgin-84
  • rfg5
  • GOLIM5
• Synonyms name
  • golgi integral membrane protein 5
• GenBank acession
  • AF085199
• Locus
  14q32.12
• Discovery year
  1999-04-28
• Entrez gene record
  9950
• Pubmed identfication
  • 2734021
  • 9443391
  • 15004235
• Classification
  • Golgins
• VEGA ID
  OTTHUMG00000171217

Gene info

• Identity
  HGNC:9967
• Gene
  RET
• Long gene name
  ret proto-oncogene
• Synonyms gene
  • HSCR1
  • MEN2A
  • MTC1
  • MEN2B
• Synonyms gene name
  • multiple endocrine neoplasia and medullary thyroid carcinoma 1
  • Hirschsprung disease 1
• Synonyms
  • PTC
  • CDHF12
  • RET51
  • CDHR16
• Synonyms name
  • cadherin-related family member 16
  • RET receptor tyrosine kinase
  • rearranged during transfection
• GenBank acession
  • BC004257
• Locus
  10q11.21
• Discovery year
  1990-07-15
• Entrez gene record
  5979
• Pubmed identfication
  • 2687772
  • 1611909
• RefSeq identity
  • NM_020975
• Classification
  • Cadherin related
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000018024
• Locus Specific Databases
  • LRG_518

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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