GSK-3 Inhibitor, AR-A014418
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Catalog number1953-5
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PricePlease ask
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Size5 mg
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Alternative_nameN-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
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DescriptionCell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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CAS Number487021-52-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₂H₁₂N₄O₄S
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Molecular Weight308.31
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Cell PermeableYes
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Purity≥98% by TLC
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SolubilitiesDMSO (30 mg/ml)
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HandlingProtect from light and air
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Tag LineA selective GSK-3 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life48 months
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MDL NumberMFCD08277040
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PubChem CID448014
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SMILESCOC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
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InChiInChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12) 16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
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InChi KeyYAEMHJKFIIIULI-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolAKR1B1, PRKN, AR, EDNRA, MIR1302-3, MIR509-3, MIR7-3, PIRC13
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Short nameGSK-3 Inhibitor, AR-A014418
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Alternative nameGSK-3 suppressor, AR-A014418
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Gene info
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Identity
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Gene
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Long gene namealdo-keto reductase family 1 member B
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Synonyms gene
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Synonyms gene name
- aldo-keto reductase family 1, member B1 (aldose reductase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Aldo-keto reductases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameparkin RBR E3 ubiquitin protein ligase
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Synonyms gene
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Synonyms gene name
- Parkinson disease (autosomal recessive, juvenile) 2, parkin
- parkinson protein 2, E3 ubiquitin protein ligase (parkin)
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Synonyms
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Synonyms name
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Locus
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Discovery year1997-08-18
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Entrez gene record
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Pubmed identfication
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Classification
- RBR E3 ubiquitin ligases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameandrogen receptor
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Synonyms gene
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Synonyms gene name
- dihydrotestosterone receptor
- spinal and bulbar muscular atrophy
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Nuclear receptor subfamily 3 group C
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameendothelin receptor type A
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-02-13
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Entrez gene record
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Pubmed identfication
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Classification
- Endothelin receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-3
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 13
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters