GSK-3 Inhibitor, AR-A014418

• Catalog number
  1953-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
• Description
  Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
• CAS Number
  487021-52-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₂H₁₂N₄O₄S
• Molecular Weight
  308.31
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (30 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A selective GSK-3 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD08277040
• PubChem CID
  448014
• PubChem CID Link
• SMILES
  COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
• InChi
  InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12) 16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
• InChi Key
  YAEMHJKFIIIULI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  GSK-3   Inhibitor   AR-A014418  
• Gene symbol
  AKR1B1, PRKN, AR, EDNRA, MIR1302-3, MIR509-3, MIR7-3, PIRC13
• Short name
  GSK-3 Inhibitor, AR-A014418
• Alternative name
  GSK-3 suppressor, AR-A014418

Gene info

• Identity
  HGNC:381
• Gene
  AKR1B1
• Long gene name
  aldo-keto reductase family 1 member B
• Synonyms gene
  • ALDR1
• Synonyms gene name
  • aldo-keto reductase family 1, member B1 (aldose reductase)
• Synonyms
  • AR
• Synonyms name
  • aldose reductase
• GenBank acession
  • J04795
• Locus
  7q33
• Discovery year
  1991-08-07
• Entrez gene record
  231
• Pubmed identfication
  • 1901827
• RefSeq identity
  • NM_001628
• Classification
  • Aldo-keto reductases
• VEGA ID
  OTTHUMG00000155322

Gene info

• Identity
  HGNC:8607
• Gene
  PRKN
• Long gene name
  parkin RBR E3 ubiquitin protein ligase
• Synonyms gene
  • PARK2
• Synonyms gene name
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin)
• Synonyms
  • PDJ
  • AR-JP
  • parkin
• Synonyms name
  • E3 ubiquitin ligase
• Locus
  6q26
• Discovery year
  1997-08-18
• Entrez gene record
  5071
• Pubmed identfication
  • 9560156
  • 9570960
• Classification
  • RBR E3 ubiquitin ligases
• VEGA ID
  OTTHUMG00000015970
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:644
• Gene
  AR
• Long gene name
  androgen receptor
• Synonyms gene
  • DHTR
  • SBMA
• Synonyms gene name
  • dihydrotestosterone receptor
  • spinal and bulbar muscular atrophy
• Synonyms
  • AIS
  • NR3C4
  • SMAX1
  • HUMARA
• Synonyms name
  • testicular feminization
  • Kennedy disease
• GenBank acession
  • M20132
• Locus
  Xq12
• Discovery year
  1986-01-01
• Entrez gene record
  367
• Pubmed identfication
  • 3353726
  • 3377788
• RefSeq identity
  • NM_000044
• Classification
  • Nuclear receptor subfamily 3 group C
• VEGA ID
  OTTHUMG00000021740
• Locus Specific Databases
  • Androgen Receptor
  • Global Variome shared LOVD
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_1406

Gene info

• Identity
  HGNC:3179
• Gene
  EDNRA
• Long gene name
  endothelin receptor type A
• Synonyms
  • ET-A
  • ETA-R
  • hET-AR
• GenBank acession
  • D90348
• Locus
  4q31.22-q31.23
• Discovery year
  1992-02-13
• Entrez gene record
  1909
• Pubmed identfication
  • 1659806
• Classification
  • Endothelin receptors
• VEGA ID
  OTTHUMG00000161354

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37517
• Gene
  PIRC13
• Long gene name
  piwi-interacting RNA cluster 13
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313925
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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