USP14 Inhibitor, IU1

• Catalog number
  1845-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone
• Description
  A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM.
• CAS Number
  314245-33-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₂₁FN₂O
• Molecular Weight
  300.37
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A USP14 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD01917473
• PubChem CID
  675434
• PubChem CID Link
• SMILES
  CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
• InChi
  InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
• InChi Key
  JUWDSDKJBMFLHE-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  USP14   Inhibitor   IU1  
• Gene symbol
  USP14
• Short name
  USP14 Inhibitor, IU1
• Alternative name
  ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) suppressor, IU1
• Alternative to gene target
  ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), TGT, USP14 and IDBG-259 and ENSG00000101557 and 9097, proteasome binding, Cell surfaces, Usp14 and IDBG-128322 and ENSMUSG00000047879 and 59025, BT.20599 and IDBG-644085 and ENSBTAG00000019214 and 505106

Gene info

• Identity
  HGNC:12612
• Gene
  USP14
• Long gene name
  ubiquitin specific peptidase 14
• Synonyms gene name
  • ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
• Synonyms
  • TGT
• GenBank acession
  • U30888
• Locus
  18p11.32
• Discovery year
  1999-02-01
• Entrez gene record
  9097
• Pubmed identfication
  • 12838346
• RefSeq identity
  • NM_005151
• Classification
  • Ubiquitin specific peptidases
• VEGA ID
  OTTHUMG00000178040

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