Anisomycin, p38 MAP kinase activator

• Catalog number
  SIH-266-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  22862-76-6
• Description
  p38 MAP kinase activator
• Molecular weight
  265,31 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  (2S,3R,4R)-4-Hydroxy-2-(4-methoxybenzyl)-3-pyrrolidinyl acetate
• Product category
  Small Molecules
• Product type
  Activator
• Chemical formula
  C14H19NO4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 - Toxic by inhilation, in contact with skin and if swallowed Hazard Phrases: H301 Precautionary Phrases: P301 + P310
• PubChem number
  253602
• Scientific context
  Anisomycin is an antibiotic which inhibits protein synthesis (1). It interferes with protein and DNA synthesis by inhibiting peptidyl transferace on the 80S ribosome system. It can activate stress-activated protein kinases, MAPkinase and other signal transduction pathways.
• Bibliography
  1. Grollman A.P. (1967) J Biol Chem. 242(13): 3226-3233.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Anisomycin (SIH-266), a Anoikis sensitizer. CAS #: 22862-76-6. Molecular Formula: C14H19NO4 . Molecular Weight: 265.31 g/mol. Chemical structure of Anisomycin, a Anoikis sensitizer (SIH-266). CAS # 22862-76-6. Molecular Formula: C14H19NO4 .
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products

• Gene target
  Anisomycin   p38   MAP   kinase   activator  
• Gene symbol
  MOAP1, MAP7, MASP2, MASP1
• Short name
  Anisomycin, p38 MAP kinase activator
• Alternative name
  Anisomycin, p38 mitogen-stimulated protein kinase phosphorylation catalyst activator

Gene info

• Identity
  HGNC:16658
• Gene
  MOAP1
• Long gene name
  modulator of apoptosis 1
• Synonyms
  • MAP-1
  • PNMA4
• Synonyms name
  • paraneoplastic Ma antigen family member 4
• GenBank acession
  • BC015044
• Locus
  14q32.12
• Discovery year
  2002-11-13
• Entrez gene record
  64112
• Pubmed identfication
  • 11060313
• Classification
  • Paraneoplastic Ma antigens
• VEGA ID
  OTTHUMG00000169184

Gene info

• Identity
  HGNC:6869
• Gene
  MAP7
• Long gene name
  microtubule associated protein 7
• Synonyms
  • E-MAP-115
• Synonyms name
  • ensconsin
• GenBank acession
  • X73882
• Locus
  6q23.3
• Discovery year
  1999-01-22
• Entrez gene record
  9053
• Pubmed identfication
  • 8408219
• RefSeq identity
  • NM_003980
• VEGA ID
  OTTHUMG00000015646

Gene info

• Identity
  HGNC:6902
• Gene
  MASP2
• Long gene name
  MBL associated serine protease 2
• Synonyms gene
  • MASP1P1
• Synonyms gene name
  • mannan-binding lectin serine protease 2
  • mannan-binding lectin serine peptidase 1 pseudogene 1
  • mannan-binding lectin serine protease 1 pseudogene 1
• Synonyms
  • Map19
  • sMAP
  • MAP-2
• Synonyms name
  • mannose-binding lectin-associated serine protease 2
  • mannose-binding lectin associated protein 19
• GenBank acession
  • X98400
• Locus
  1p36.22
• Discovery year
  1998-12-17
• Entrez gene record
  10747
• Pubmed identfication
  • 9087411
  • 9777418
• RefSeq identity
  • NM_006610
• Classification
  • Sushi domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000002121
• Locus Specific Databases
  • MASP2base: Mutation registry for MASP-2 deficiency
  • LRG_82

Gene info

• Identity
  HGNC:6901
• Gene
  MASP1
• Long gene name
  MBL associated serine protease 1
• Synonyms gene
  • CRARF
  • PRSS5
• Synonyms gene name
  • mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan binding lectin serine peptidase 1
• Synonyms
  • MASP
  • Map44
  • MASP-3
  • MAP-1
• Synonyms name
  • C4/C2 activating component of Ra-reactive factor
  • mannose-binding lectin-associated serine protease 1
• GenBank acession
  • D28593
• Locus
  3q27.3
• Discovery year
  1995-07-06
• Entrez gene record
  5648
• Pubmed identfication
  • 8018603
  • 8240317
• RefSeq identity
  • NM_001879
• Classification
  • Serine proteases
  • Complement system activation components
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000156461
• Locus Specific Databases
  • LRG_349

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