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Mouse Monoclonal clone 9E10 IgG1 to Human MYC c Myc Antibody

Mouse Monoclonal clone 9E10 IgG1 to Human MYC c Myc Antibody is available 2 times from Mbs monoclonals labs

GEN245318 | Mouse Monoclonal [clone 9E10] (IgG1) to Human MYC / c-Myc Antibody size: 50ug | 658.49 USD

Catalog number GEN245318
Price 658.49 USD
Size 50ug
Species reactivity Chimpanzee, Gorilla, Human (Homo sapiens) Predicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Specificity and cross-reactivity The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Purification method Protein G Purified
Form/Appearance PBS, 15 mM sodium azide, approx., pH 7.4.
Concentration 1 miligram per 1 mililiter
Storage and shipping For short term storage keep the antibody at +4 degrees Celsius. For longer storage the antibody should be kept at -20 degrees Celsius. Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity.
Tested applications: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
1. Gene info
Identity 7553
Gene MYC
Long gene name MYC proto-oncogene, bHLH transcription factor
Synonyms gene name
  • v-myc avian myelocytomatosis viral oncogene homolog
Synonyms
  • c-Myc
  • bHLHe39
  • MYCC
Locus 8q24.21
Discovery year 2001-06-22
Entrez gene record 4609
Classification
  • Basic helix-loop-helix proteins
Havana BLAST/BLAT OTTHUMG00000128475
MeSH Data
Name Blotting, Western
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    anti-MYC antibody Immunohistochemistry (IHC) (IHC)  image#Mouse#.jpg#Human#.jpg

GEN246580 | Mouse Monoclonal [clone 9E10] (IgG1) to Human MYC / c-Myc Antibody size: 50ug | 658.49 USD

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Also known as MYC / c-Myc
Other names myc proto-oncogene protein; Myc proto-oncogene protein; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc avian myelocytomatosis viral oncogene homolog; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Category Antibodies
Subcategory Mnoclonal antibodies
Gene name MYC
Gene name synonims c-Myc
Other gene names MYC; MYC; MRTL; MYCC; c-Myc; bHLHe39; BHLHE39; bHLHe39
Clonality Monoclonal
Immunoglobulin isotype IgG1
Clone 90000000000
Host organism Mouse (Mus musculus)
Properties If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name Mus musculus
French translation anticorps
Gene targetMonoclonal 9E10] IgG1 MYC c-Myc
Short name Mouse Monoclonal [clone 9E10] (IgG1) MYC / c-Myc Antibody
Technique Mouse monoclonal, Antibody, Mouse
Host mouse monoclonal
Isotype IgG1
Species Human
Alternative name Mouse monoclonal [clonality 9E10] (IgG1) to H. sapiens v-myc myelocytomatosis viral oncogene homolog (avian) / c-v-myc myelocytomatosis viral oncogene homolog (avian) (Antibody to)
Alternative technique antibodies
Alternative to gene target v-myc myelocytomatosis viral oncogene homolog (avian), bHLHe39 and c-Myc and MRTL and MYCC, MYC and IDBG-35442 and ENSG00000136997 and 4609, E-box binding, nuclei, Bmyc and IDBG-147082 and ENSMUSG00000049086 and 107771, MYC and IDBG-644147 and ENSBTAG00000008409 and 511077
Clone name 9E10
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  • Monoclonal
  • 9E10]
  • IgG1
  • MYC
  • c-Myc
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