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Alternative_name
(2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
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Description
Cell-permeable. A potent, slow binding dipeptidyl peptidase IV inhibitor with IC₅₀ values of 3, 5, 8, and 8 nM for rat, canine, human and monkey enzymes respectively. Acts as a long-acting hypoglycemic agent.
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CAS Number
440100-64-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₇H₂₄N₆O
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Molecular Weight
328.41
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~100 mM) or EtOH (~ 20 mM) or 1 eq. HCl (50 mM)
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Handling
Protect from light and air
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Tag Line
A potent DPP IV Inhibitor,
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
48 months
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MDL Number
MFCD07364044
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PubChem CID
9818824
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SMILES
CC1(CCN(CC1)C2=NC=CC=N2)NCC(=O)N3CCCC3C#N
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InChi
InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
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InChi Key
JERPHRNGJBSFAP-AWEZNQCLSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
