NIK Antibody

• Catalog number
  3193R-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  NIK
• Target Alternative Name
  MAP3K14, hsNIK, FTDCR1B, HSNIK , EC 2.7.11.25
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat, dog, hamster
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 927of human NIK
• Accession
  Q99558
• Gene Id
  9020
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) affinity purified rabbit anti-NIK polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually
• Description
  NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated from a human B cell cDNA library and contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to IkB phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NIK  
• Gene symbol
  MAP4K4, MAP3K14
• Short name
  NIK Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  NIK (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6866
• Gene
  MAP4K4
• Long gene name
  mitogen-activated protein kinase kinase kinase kinase 4
• Synonyms
  • HGK
  • NIK
  • FLH21957
• Synonyms name
  • HPK/GCK-like kinase
  • hepatocyte progenitor kinase-like/germinal center kinase-like kinase
• GenBank acession
  • AF096300
• Locus
  2q11.2
• Discovery year
  1999-09-07
• Entrez gene record
  9448
• Pubmed identfication
  • 9890973
  • 9734811
  • 9135144
• RefSeq identity
  • NM_004834
• Classification
  • Mitogen-activated protein kinase kinase kinase kinases
• VEGA ID
  OTTHUMG00000155394

Gene info

• Identity
  HGNC:6853
• Gene
  MAP3K14
• Long gene name
  mitogen-activated protein kinase kinase kinase 14
• Synonyms
  • NIK
  • HSNIK
  • FTDCR1B
  • HS
• Synonyms name
  • serine/threonine protein-kinase
• GenBank acession
  • Y10256
• Locus
  17q21.31
• Discovery year
  2000-08-11
• Entrez gene record
  9020
• Pubmed identfication
  • 9020361
• RefSeq identity
  • NM_003954
• Classification
  • Mitogen-activated protein kinase kinase kinases
• VEGA ID
  OTTHUMG00000180364
• Locus Specific Databases
  • LRG_1222

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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