ML-324

Alternative_name

N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
Description

Cell-permeable. ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.
CAS Number

1222800-79-5
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₁H₂₃N₃O₂
Molecular Weight

349.43
Cell Permeable

Y
Purity

≥98% by TLC
Solubilities

DMSO (~ 20 mg/ml, warm) or EtOH (~ 6 mg/ml, warm)
Handling

Protect from air and light
Tag Line

AJMJD2 histone demethylase inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD28053518
SMILES

OC1=CC(C2=CC=C(C(NCCCN(C)C)=O)C=C2)=CC3=CC=CN=C31
InChi

InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
InChi Key

QDBVSOZTVKXUES-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes