MOUSE Anti-HUMAN SIGLEC-5/SIGLEC-14 Antibody

  • Catalog number
    GEN224725
  • Price
    Please ask
  • Size
    100ug
  • Also known as
    SIGLEC-5/SIGLEC-14
  • Other names
    sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin 5; sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding immunoglobulin-like lectin 5; sialic acid binding Ig-like lectin 5; CD33 antigen-like 2; Obesity-binding protein 2
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    SIGLEC5; SIGLEC5; CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; CD33L2; OBBP2; Siglec-5; OB-BP2
  • Gene name synonims
    SIGLEC5; SIGLEC5; CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; CD33L2; OBBP2; Siglec-5; OB-BP2
  • Other gene names
    SIGLEC5; SIGLEC5; CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; CD33L2; OBBP2; Siglec-5; OB-BP2
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgG1
  • Clone
    1A5
  • Host organism
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    SIGLEC-5/SIGLEC-14 This item recognises human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage. Clone 1A5, is one of several Siglec-5 antibodies which also recognises human Siglec-14 (Sialic acid-binding Ig-like lectin 14) Siglec-14 shares an almost identical sequence with Siglec-5 within the first two Ig-like domains, indicating partial gene conversion between these two Siglecs, also evident in other primate species. Siglec-5 is highly related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), and mediates sialic-acid dependent binding to cells, as well as acting as an inhibitory receptor in the down-regulation of cell activation. Structurally, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), which plays a part in the modulation of cellular responses, and when phosphorylated, can bind to the SH2 domain of several SH2-containing phosphatases. Siglec-14 is a putative sialic-acid binding adhesion molecule, and member of the Ig superfamily, predominantly expressed in hematopoietic tissues, which has been shown to associate with the activating adapter protein DAP12. Clone 1A5 has been show to cross react with Chimpanzee; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
  • Purification method
    N/A
  • Form Appearance
    Purified (Purified IgG - liquid)
  • Concentration
    IgG concentration 1.0 mg/ml
  • Storage and shipping
    Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
  • Tested applications
    Flow Cytometry (FACS), Immunofluorescence (IF), ELISA (EIA), Immunoprecipitation (IP)
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Test
    MBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • French translation
    anticorps
  • Gene target
    SIGLEC-5/SIGLEC-14  
  • Gene symbol
    SIGLEC5, SIGLEC12, CD22, SIGLEC16, SIGLEC10, CD33, SIGLEC8, MAG, SIGLEC14, SIGLEC6
  • Short name
    MOUSE Anti- SIGLEC-5/SIGLEC-14 Antibody
  • Technique
    anti-Human, Antibody, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, antibodies against human proteins, mouses
  • Host
    mouse
  • Species
    Human, Humans, Mouses
  • Alternative name
    Anti-MOUSE ANTI HUMAN SIGLEC-5/SIGLEC-14
  • Alternative technique
    antibodies, murine
Gene info
Gene info
Gene info
Gene info
  • Identity
    HGNC:24851
  • Gene
    SIGLEC16
  • Long gene name
    sialic acid binding Ig like lectin 16
  • Synonyms gene
  • Synonyms gene name
    • sialic acid binding Ig-like lectin, pseudogene 16
    • sialic acid binding Ig-like lectin 16 (gene/pseudogene)
    • sialic acid binding Ig like lectin 16 (gene/pseudogene)
  • Synonyms
  • GenBank acession
  • Locus
    19q13.33
  • Discovery year
    2004-10-20
  • Entrez gene record
    400709
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • C2-set domain containing
    • I-set domain containing
    • Sialic acid binding Ig like lectins
    • V-set domain containing
  • VEGA ID
    OTTHUMG00000183074
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
    Blotting, Western
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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MOUSE Anti HUMAN SIGLEC 5 SIGLEC 14 Antibody - Gentaur.com
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