Tudor domain-containing protein 4 (hTDRD4, domain 30-139aa), human recombinant

  • Catalog number
    7251-1000
  • Price
    Please ask
  • Size
    1 mg
  • Synonyms
    RING finger protein 17, Tudor domain-containing protein 4, TDRD4, RNF17
  • Alternative_names
    RING finger protein 17, Tudor domain-containing protein 4, TDRD4, RNF17
  • Description
    Involved in RISC complex and interaction with AEG-1 oncogene
  • Recombinant
    Yes
  • Source
    E. coli
  • Purity by SDS PAGE
    ≥98%
  • Assay
    SDS-PAGE
  • Molecular Weight
    14.6 kDa (110 aa + NT 6 x His-tag)
  • Storage Temp
    -80°C
  • Shipping
    Dry Ice
  • Shelf Life
    12 months
  • Concentration
    1 mg/ml
  • Appearance
    Liquid
  • Physical form description
    1.0 mg/ml solution in 25 mM Tris (pH 8.0) buffer containing 20% glycerol.
  • Background Information
    Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The Tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The Tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. TDRD4 is a candidate CT antigen expressed in a subset of liver cancers. The recombinant protein includes TDRD4 (domain 30-139 aa) with N-terminal His-tag.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    SNORD114-30, SNORD116-30, SNORD115-30, IGKV2-30, RNU6-30P, IGHV3-30, IGLV3-30, IGHVII-30-21, IGHVII-30-1, IGKV2D-30
  • Short name
    Tudor domain- protein 4 (hTDRD4, domain 30-139aa), recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    Tudor domain-containing protein 4 (hTDRD4, domain 30-139aa), H. sapiens Rec.
  • Alternative technique
    rec
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    RNA, U6 small nuclear 30, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • RNA, U6 small nuclear 30
  • Locus
  • Discovery year
    2008-06-10
  • Entrez gene record
  • RefSeq identity
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin lambda variable 3-30 (pseudogene)
  • Synonyms gene name
    • immunoglobulin lambda variable 3-30
    • immunoglobulin lambda variable 3-30 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-05-08
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin lambda locus at 22q11.2
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable (II)-30-1 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable (II)-30-1
    • immunoglobulin heavy variable (II)-30-1 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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