Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDC2/PHC2
Specificity This is a highly specific antibody against HDC2/PHC2.
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms Early development regulatory protein 2; hPH2; early development regulator 2 homolog of polyhomeotic 2; early development regulator 2 like; EDR2; MGC163502; mph2; PH2; PHC2; PHC2_HUMAN; polyhomeotic 2; polyhomeotic like 2; Polyhomeotic-like protein 2.
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen Early development regulatory protein 2;hPH2;early development regulator 2 (homolog of polyhomeotic 2);Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC2 (polyhomeotic-like protein 2), also known as early development regulatory protein 2, is an 858 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Phosphorylated upon DNA damage, PHC2 contains one SAM (sterile alpha motif) domain and one FCS-type zinc finger.
Concentration 1ug per 1ul
Target Antigen HDC2/PHC2
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.