anti-PUMA Antibody

• Catalog number
  3043
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  PUMA Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
• Gene names
  PUMA Antibody: JFY1, PUMA, JFY-1, Bcl-2-binding component 3
• Antibodie s label
  unlabelled serum
• Purity
  PUMA Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  PUMA antibody was made against a synthetic peptide corresponding to 14 amino acids near the amino terminus of human PUMA-a. This sequence is identical between a and b forms of the PUMA proteins.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  PUMA antibody can be used for detection of PUMA by Western blot at 2 ug/mL. Antibody can also detect PUMA by immunohistochemistry at 10 ug/mL. For immunofluorescence start at 10 ug/mL.
• Suspention pH azide
  PUMA Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  PUMA antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  15193488
• Ncbi nr
  NP_055232
• KDa
  23 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  27113
• GENE symbol
  BBC3
• Antigene name
  BCL2 binding component 3
• Source
  Homo sapiens
• Protein nr
  Q96PG8
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PUMA  
• Gene symbol
  BBC3, HCAR2
• Short name
  anti-PUMA Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toPUMA (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17868
• Gene
  BBC3
• Long gene name
  BCL2 binding component 3
• Synonyms
  • JFY1
  • PUMA
• Synonyms name
  • p53-upregulated modulator of apoptosis
• GenBank acession
  • AF332558
• Locus
  19q13.32
• Discovery year
  2002-07-22
• Entrez gene record
  27113
• Pubmed identfication
  • 11463392
  • 11572983
• RefSeq identity
  • NM_014417
• Classification
  • BCL2 homology region 3 (BH3) only
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000183489

Gene info

• Identity
  HGNC:24827
• Gene
  HCAR2
• Long gene name
  hydroxycarboxylic acid receptor 2
• Synonyms gene
  • GPR109A
• Synonyms gene name
  • G protein-coupled receptor 109A
• Synonyms
  • HCA2
  • HM74A
  • PUMAG
  • Puma-g
  • NIACR1
• Synonyms name
  • niacin receptor 1
• GenBank acession
  • AY148884
• Locus
  12q24.31
• Discovery year
  2004-04-22
• Entrez gene record
  338442
• Pubmed identfication
  • 21167710
  • 12522134
  • 12646212
  • 19141678
  • 18983141
  • 21454438
• RefSeq identity
  • NM_177551
• Classification
  • Hydroxycarboxylic acid receptors
• VEGA ID
  OTTHUMG00000162722

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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