C646, p300/CBP Inhibitor

• Catalog number
  1948-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
• Description
  Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (
• CAS Number
  328968-36-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₁₉N₃O₆
• Molecular Weight
  445.42
• Cell Permeable
  Yes
• Purity
  ≥98% by NMR
• Solubilities
  DMSO (25 mM)
• Handling
  Protect from light and air
• Tag Line
  A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD01784780
• PubChem CID
  1285941
• PubChem CID Link
• SMILES
  CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
• InChi
  InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
• InChi Key
  HEKJYZZSCQBJGB-UNOMPAQXSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  C646   p300/CBP   Inhibitor  
• Gene symbol
  PAG1, OPN1LW, CREBBP
• Short name
  C646, p300/CBP Inhibitor
• Alternative name
  C646, p300/CBP suppressor

Gene info

• Identity
  HGNC:30043
• Gene
  PAG1
• Long gene name
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
• Synonyms gene name
  • phosphoprotein associated with glycosphingolipid microdomains 1
• Synonyms
  • PAG
  • CBP
• Synonyms name
  • Csk-binding protein
  • transmembrane adaptor protein PAG
• GenBank acession
  • AF240634
• Locus
  8q21.13
• Discovery year
  2005-04-25
• Entrez gene record
  55824
• Pubmed identfication
  • 10790433
• RefSeq identity
  • NM_018440
• VEGA ID
  OTTHUMG00000164592

Gene info

• Identity
  HGNC:9936
• Gene
  OPN1LW
• Long gene name
  opsin 1, long wave sensitive
• Synonyms gene
  • CBBM
  • RCP
  • CBP
• Synonyms gene name
  • color blindness, protan
  • red cone photoreceptor pigment
  • opsin 1 (cone pigments), long-wave-sensitive
• Synonyms
  • COD5
• Synonyms name
  • cone dystrophy 5 (X-linked)
• GenBank acession
  • Z68193
• Locus
  Xq28
• Discovery year
  2001-06-22
• Entrez gene record
  5956
• RefSeq identity
  • NM_020061
• Classification
  • Opsin receptors
• VEGA ID
  OTTHUMG00000034295
• Locus Specific Databases
  • Mutations of the Photopigments - Red (RCP), Green (GCP), and Blue Cone Pigment (BCP)

Gene info

• Identity
  HGNC:2348
• Gene
  CREBBP
• Long gene name
  CREB binding protein
• Synonyms gene
  • RSTS
• Synonyms gene name
  • Rubinstein-Taybi syndrome
• Synonyms
  • RTS
  • CBP
  • KAT3A
• GenBank acession
  • U85962
• Locus
  16p13.3
• Discovery year
  1995-01-10
• Entrez gene record
  1387
• Pubmed identfication
  • 8413673
• RefSeq identity
  • NM_004380
• Classification
  • Bromodomain containing
  • Zinc fingers ZZ-type
  • Lysine acetyltransferases
• VEGA ID
  OTTHUMG00000129431
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_1426

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