NCF1/p47 phox(Ser359) Antibody, ALEXA FLUOR 647

• Catalog number
  bs-11445R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  NCF1/p47 phox(Ser359) Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-NCF1/p47 phox Ser359 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  NCF1/p47 phox Ser359
• Specificity
  This is a highly specific antibody against NCF1/p47 phox Ser359.
• Modification
  Phosphorylation
• Modification Site
  Ser359
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
• Gene ID Number
  653361
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  NCF1Ser359; p47 phoxSer359; NCF1 phospho S359; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-NCF1/p47 phox Ser359 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  NCF1/p47   phox   Ser359  
• Gene symbol
  NCF1
• Short name
  Anti-NCF1/p47 phox Ser359
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  NCF1/p47 phox(Ser359) Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  neutrophil cytosolic factor 1, NCF1 and IDBG-21570 and ENSG00000158517 and 653361, phosphatidylinositol-3, Plasma membranes, Ncf1 and IDBG-202592 and ENSMUSG00000015950 and 17969, NCF1 and IDBG-639883 and ENSBTAG00000003305 and 281345

Gene info

• Identity
  HGNC:7660
• Gene
  NCF1
• Long gene name
  neutrophil cytosolic factor 1
• Synonyms gene name
  • neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1)
• Synonyms
  • p47phox
  • NOXO2
  • NCF1A
  • SH3PXD1A
• Synonyms name
  • NADPH oxidase organizer 2
  • chronic granulomatous disease, autosomal 1
• GenBank acession
  • M25665
• Locus
  7q11.23
• Discovery year
  1989-05-25
• Entrez gene record
  653361
• RefSeq identity
  • NM_000265
• VEGA ID
  OTTHUMG00000149965
• Locus Specific Databases
  • NCF1base: Mutation registry for autosomal recessive chronic granulomatous disease (CGD), deficiency of p47phox
  • LRG_87

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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