Angiostatin K1-3, human recombinant

• Catalog number
  4920-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Angiostatin K1-3, Angiostatin Kringles 1-4
• Alternative_names
  Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen
• Description
  A specific inhibitor of endothelial cell growth and angiogenesis
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10⁵ Units/mg.
• Results
  0.55×10⁵ Units/mg.
• Molecular Weight
  30.0 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  From 20 mM Sodium Acetate, pH 5.5, 4% mannitol
• Reconstitution Instructions
  Reconstitute in sterile distilled H₂O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
• Background Information
  Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Angiostatin   K1-3  
• Gene symbol
  KRT13, KCNG1, COLEC11, MIR1302-3, MIR509-3, MIR7-3, PIRC13, PIRC11
• Short name
  Angiostatin K1-3, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Angiostatin K1-3, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6415
• Gene
  KRT13
• Long gene name
  keratin 13
• Synonyms gene name
  • keratin 13, type I
• Synonyms
  • K13
  • CK13
  • MGC3781
  • MGC161462
• Synonyms name
  • keratin, type I cytoskeletal 13
  • cytokeratin 13
• Locus
  17q21.2
• Discovery year
  1990-11-05
• Entrez gene record
  3860
• Pubmed identfication
  • 16831889
• RefSeq identity
  • NM_153490
• Classification
  • Keratins, type I
• VEGA ID
  OTTHUMG00000133434

Gene info

• Identity
  HGNC:6248
• Gene
  KCNG1
• Long gene name
  potassium voltage-gated channel modifier subfamily G member 1
• Synonyms gene
  • KCNG
• Synonyms gene name
  • potassium voltage-gated channel, subfamily G, member 1
• Synonyms
  • Kv6.1
  • kH2
  • K13
• GenBank acession
  • AF033383
• Locus
  20q13.13
• Discovery year
  1993-03-22
• Entrez gene record
  3755
• Pubmed identfication
  • 9434767
  • 16382104
• RefSeq identity
  • NM_002237
• Classification
  • Potassium voltage-gated channels
• VEGA ID
  OTTHUMG00000032745

Gene info

• Identity
  HGNC:17213
• Gene
  COLEC11
• Long gene name
  collectin subfamily member 11
• Synonyms
  • MGC3279
  • CL-K1
  • CL-11
• Synonyms name
  • Collectin K1
• GenBank acession
  • BC000078
• Locus
  2p25.3
• Discovery year
  2001-11-20
• Entrez gene record
  78989
• RefSeq identity
  • NM_024027
• Classification
  • Collectins
  • C-type lectin domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000090304
• Locus Specific Databases
  • LRG_350

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37517
• Gene
  PIRC13
• Long gene name
  piwi-interacting RNA cluster 13
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313925
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37515
• Gene
  PIRC11
• Long gene name
  piwi-interacting RNA cluster 11
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313897
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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