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Products_type
Antibody
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Products_short_name
[LEPR / Leptin Receptor]
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Products_name_syn
[Anti-LEPR / Leptin Receptor Antibody (Internal) IHC-plus; LEPR; CD295 antigen; HuB219; LEP-R; OB receptor; LEPRD; OB-R; OBR; CD295; DB; Leptin receptor; Human LEPR; Leptin Receptor]
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Other_names
[leptin receptor isoform 1; Leptin receptor; leptin receptor; huB219; OB receptor; leptin receptor; HuB219; OB receptor; OB-R; CD_antigen: CD295]
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Products_gene_name
[LEPR]
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Other_gene_names
[LEPR; LEPR; OBR; OB-R; CD295; LEP-R; LEPRD; DB; OBR; LEP-R; OB-R]
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Clonality
Polyclonal
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Reactivity
Gorilla, Human Predicted Reactivity: Monkey, Dog, Horse (at least 90% immunogen sequence identity)
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Specificity
Human LEPR / Leptin Receptor. This antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1).
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Purity
Immunoaffinity Purified
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Form
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
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Concentration
0.5 mg/ml
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Storage_stability
Store at -20 degree C. Minimize freezing and thawing.
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Tested_application
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
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Latin name
Capra aegagrus hircus
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene
Human or mouse Leptin (from Greek λεπτός leptos, "thin") the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. ELISA kits and peptides and antibodies are available.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
LEPR
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Short name
Goat Polyclonal LEPR / Leptin Receptor
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Technique
Polyclonal, Goat, goats, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Host
Goat, The goat polyclonal antibodies are directed against human genes or rabbit or mouse IgGs (H +L) chain primary antibodies and conjugated for detection. It are very good secondary antibodies that are affinity purified and have a good affinity themselves too. Often KLH is coupled to the antigen so anti KLH can be present in the vial.
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Species
Human, Goats, Humans
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Alternative name
caprine polyclonal to H. sapiens leptin receptor / Leptin Receptor
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Alternative technique
polyclonals, caprine
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Alternative to gene target
leptin receptor, CD295 and LEP-R and LEPRD and OB-R and OBR, LEPR and IDBG-99469 and ENSG00000116678 and 3953, identical protein binding, Extracellular, Lepr and IDBG-167734 and ENSMUSG00000057722 and 16847, LEPR and IDBG-638266 and ENSBTAG00000005910 and 497205,785813
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