This antibody has been succesfully tested for use in following methods: Western blot
Target of this antibody: BRD3-BD2
Alternative names of antibody target: KIAA0043, RING3L
Recommended usage: Western blot: 1-4 µg/ml.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
Antibody host: Rabbit
This antibody reacts with: Human
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
Purification method: Affinity Purified Antibody
Immunogene sequence: Recombinant human BRD3-BD2 protein (Cat # 7257)
How to handle this antibody: The antibody solution should be gently mixed before use.
Background information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people.
Form of antibody: Liquid
Concentration of antibody: 0.5 mg/ml
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Short name anti-BRD3-BD2 Antibody
Technique Antibody, anti
Alternative name antibody to-BRD3-BD2 (Antibody to)
Alternative technique antibodies