GW 0742 is a potent and selective PPARδ agonist (EC₅₀ = 1.1 nM) that displays 1,000-fold selectivity over other human PPAR subtypes. Therapeutically has shown to have effect on pulmonary damage, inflammatory and apoptotic parameters in mice. It increases the rate of fatty acid oxidation and provides ischemia /reperfusion injury protection in cardiomyocytes. It has been reported to have neuroprotective properties and enhances interleukin-6 (IL-6), IL-8 expression.
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
DMSO (>40 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
GW-0742 for activation
GW-0742 to measure cellular activation
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