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Anti-CEA (5F2) Monoclonal, ALEXA Fluor 594

Anti-CEA (5F2) Monoclonal, ALEXA Fluor 594 is available 1 time from Bioss monoclonal antibodies labs

GENTObsm-4793M-A594 | Anti-CEA (5F2) Monoclonal, ALEXA Fluor 594 size: 149 microliters | 562.59 USD

Catalog number GENTObsm-4793M-A594
Price562.59 USD
Size 149 microliters
1. Gene info
Identity1819
Long gene name carcinoembryonic antigen related cell adhesion molecule 7
Synonyms gene
Synonyms gene name
  • carcinoembryonic antigen-related cell adhesion molecule 7
Synonyms
GenBank acession
Locus19q13.2
Discovery year 1991-09-12
Entrez gene record1087
Pubmed identfication
RefSeq identity
Classification
  • Immunoglobulin like domain containing
  • V-set domain containing
  • Carcinoembryonic antigen related cell adhesion molecule family
Havana BLAST/BLATOTTHUMG00000151063
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedIn a cohort with non-small cell lung cancer, the mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with both in 3.81%. Mutation was more common in non-smokers than smokers, and in adenocarcinoma more than squamous cell carcinoma.
results from transgenic mouse models up-regulated indicate non-mutated adhesion molecules could have a significant instrumental role in human cancer
Study shows that it is possible to use ultrasound to amplify and localize the source of CEA levels in blood of tumor-bearing mice and will allow for a previously undescribed way to determine the presence and localization of disease more accurately.
Data show that Ad5 immune mice bearing CEA-expressing tumors that were treated with Ad5 [E1-, E2b-]-CEA had increased anti-tumor response as compared with Ad5 [E1-]-CEA treated mice.
Vaccination with the plasmid for the triple repeated CEA peptides induced stronger Th1 responses
preoperative expression level is a prognostic factor in patients with stage I non-small cell lung cancer
The significant expression of IMP3 and CEA in less well-differentiated foci of mucinous MDA may be helpful in the diagnosis of mucinous MDA to some extent.
Data indicate that serum carcino-embryonic antigen (CEA) has a tendency to increase over time in patients with urinary diversion (UD) but is not a valuable marker of secondary neoplasms in these patients.
CEA acts to promote the metastatic dissemination of tumor cells. On depletion of CEA, the metastatic potential of LS174T cells is dramatically reduced.
upregulated transcription correlates with tumor size in Non-Small-Cell Lung Cancer
Product images
    anti-#.jpgGENTObsm#.jpg#anti-#.jpgHT29 Cell lysates probed with CEA (5F2) Monoclonal Antibody, unconjugated (bsm-4793M) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Modification Not modified
Clonality Monoclonal Antibodies
Host organism Mouse (Mus musculus)
Background information CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Specificity Highly specific antibody against CEA
Applications with corresponding dilutions IF(IHC-P)(1:50-200)
Conjugated with ALEXA FLUOR 594
Gene ID 1048
Cross Reactive species Human (Homo sapiens)
Clone 5F2
Cross Reactive Species details No significant cross reactivity is observed
Synonyms Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.
Applications IF(IHC-P)
Alternative name 1 CEA (5F2) Monoclonal Antibody, ALEXA FLUOR® 594 Conjugated
Concentration 1ug per 1ul
Purification method Purified by Protein G.
Advisory Cycles of freezing and thawing should be avoided as such cycles may denature the peptide chains of the antibody and reduce its affinity, specificity and reactivity. For antibodies in a liquid form or reconstituted lyophilized antibodies - small amounts of the soultion could be captured on the cap or the walls of the container. Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom.
Type Conjugated Primary Antibody
Excitation emission 590nm/617nm
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target Protein/Peptide CEA
Alternative name 2 CEA (5F2) Monoclonal anti-, ALEXA FLUOR 594 Conjugated
Antigen Source KLH conjugated synthetic peptide derived from Human CEA/CEACAM5
Properties For facs or microscopy Alexa 1 conjugate.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Gene targetCEA 5F2 Monoclonal
Short name Anti-CEA (5F2) Monoclonal,
Technique anti
Label ALEXA FLUOR 594
Alternative name antibody to-CEA (5F2) monoclonal, ALEXA Fluor 594
Alternative technique antibodies
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