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Synonyms
Elcatonin, 60731-46-6
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Alternative_names
Elcatonin, 60731-46-6
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Description
A calcitonin derivative used as an anti-parathyroid agent
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Recombinant
No
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Source
Synthetic
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Purity by SDS PAGE
≥94%
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Assay
SDS-PAGE
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Purity
≥94%
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Biological activity
Biological Activity (based on net peptide) was found to be 6065 IU/mg
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Storage Temp
-20°C
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Shipping
gel pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Sterile filtered and lyophilized with no additives
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Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile dW to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 2-7 days and at -20 °C for future use.
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Background Information
Elcatonin is a Calcitonin derivative which is transformed from eel´s calcitonin by changing the S-S bond into the stable C-N bond. It inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine. Meanwhile, it inhibits renal tubules reabsorbing calcium, phosphorus and sodium and keeps blood calcium at normal level. It is mainly used for remitting or eliminating the pain caused by Osteoporosis. Elcatonin synthetic is a single, non-glycosylated polypeptide chain containing 31 amino acids.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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