Difluoromethylornithine, ODC Inhibitor
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Catalog number
SIH-200-50MG
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Price
Please ask
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Size
50 mg
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Stock availabilitIn Stock
In Stock
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CAS number
70052-12-9
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Description
ODC Inhibitor
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Molecular weight
218,63 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
N2-(Difluoromethyl)ornithine, DFMO, Eflornithine
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C6H12F2N2O2•HCl
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 75 mM in water
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
3009
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Scientific context
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays anti-apoptotic, anti-angiogenic and anti-parasitic activity.
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Bibliography
1. Malhotra B., Noveck R., Behr D., Palmisano M. (2001) J Clin Pharmacol. 41: 972-978.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Difluoromethylornithine (SIH-200), a Inhibits polyamine biosynthesis. CAS #: 70052-12-9. Molecular Formula: C6H12F2N2O2 * HCl. Molecular Weight: 218.63 g/mol. Chemical structure of Difluoromethylornithine, a Inhibits polyamine biosynthesis (SIH-200). CAS # 70052-12-9. Molecular Formula: C6H12F2N2O2 * HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
ODC1, SLC25A21, AZIN2
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Short name
Difluoromethylornithine, ODC Inhibitor
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Alternative name
Difluoromethylornithine, ODC suppressor
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Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
antizyme inhibitor 2
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Synonyms gene
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Synonyms gene name
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2005-06-06
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Entrez gene record
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Pubmed identfication
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VEGA ID
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