Anti-TNF-α (Humicade) Biotinylated Antibody
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Catalog number
A2182-50
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Price
Please ask
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Size
50 µg
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Antibody Target
TNF-α
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Target Alternative Name
BAY 103356, BAY W 3356, CDP 571, DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha, APC1 Protein
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Antibody Type
Monoclonal
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Clone
CDP571
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Species Reactivities
Human
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Immunogen Sequence
Human TNF-α
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Accession
P01375
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Gene Id
7124
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin
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Purification
Affinity purified using protein A
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Application
ELISA
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Application And Usages
ELISA 0.1 µg - 1 µg/ml
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Description
Recombinant monoclonal antibody to TNF-α. Manufactured using recombinant technology with variable regions (i.e. specificity) from the hybridoma CDP 571 (Humicade). The antibody binds specifically to TNF-α, a pro-inflammatory cytokine that stimulates the release of other cytokines e.g. IL-1, IL-6, and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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ELISA Verified
1
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
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French translation
anticorps
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Gene target
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Gene symbol
TNF, TNFRSF1A, TNFRSF1B, LTBR
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Short name
Anti-TNF-α (Humicade) Biotinylated Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG4, kappa
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Alternative name
Antibody toTNF-α (Humicade) Biotinylated (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
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Gene info
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Identity
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Gene
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Long gene name
tumor necrosis factor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor (TNF superfamily, member 2)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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