AAL 993, VEGFR inhibitor
-
Catalog numberSIH-424-25MG
-
PricePlease ask
-
Size25 mg
-
-
Stock availabilitIn StockIn Stock
-
CAS number269390-77-4
-
DescriptionVEGFR inhibitor
-
Molecular weight371,4 g/mol
-
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Growth Factor Receptor Inhibitors
-
Other name2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
-
Product categorySmall Molecules
-
Product typeInhibitor
-
Chemical formulaC20H16F3N3O
-
OriginSynthetic
-
Purity pourcentage≥98% (TLC)
-
Soluble inSoluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml)
-
Physical appearancePale yellow solid
-
Storage recommendations-20ºC
-
Shipping recommendationsShipped Ambient
-
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
-
PubChem number6398883
-
Scientific contextAAL-993 is a very potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3, as well as PDGFR-β, c-Kit and CSF-1R at higher concentrations.
-
Bibliography1. Manley P.W., et al. (2004) Biochimica Biophysica Acta. 1697(1-2): 17–27. 2. Ban H.S., Uno M., & Nakamura H. (2010) Cancer Letters. 296(1): 17–26.
-
Release date1-Oct-2014
-
PubMed numberRefer to PubMed
-
Tested applicationsTo be tested
-
Tested reactivityTo be tested
-
Representative figure legendChemical structure of AAL 993 (SIH-424), a VEGFR inhibitor. CAS #: N/A. Molecular Formula: C20H16F3N3O. Molecular Weight: 371.4 g/mol. Chemical structure of AAL 993, a VEGFR inhibitor (SIH-424). CAS # N/A. Molecular Formula: C20H16F3N3O.
-
Warning informationNon-hazardous
-
Country of productionCanada
-
Total weight kg0.25
-
Net weight g0.025
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolFLT4, KDR
-
Short nameAAL 993, VEGFR inhibitor
-
Alternative nameAAL 993, VEGFR suppressor
-
Gene info
-
Identity
-
Gene
-
Long gene namefms related receptor tyrosine kinase 4
-
Synonyms gene name
- fms-related tyrosine kinase 4
- fms related tyrosine kinase 4
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1991-10-25
-
Entrez gene record
-
Pubmed identfication
-
Classification
- I-set domain containing
- Receptor tyrosine kinases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namekinase insert domain receptor
-
Synonyms gene name
- kinase insert domain receptor (a type III receptor tyrosine kinase)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1991-07-10
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
- V-set domain containing
-
VEGA ID
-
Locus Specific Databases