MK-4827

  • Catalog number
    9462-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; Niraparib
  • Description
    MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.
  • CAS Number
    1038915-60-4
  • Structure Available
    Yes
  • Molecular Formula
    C₁₉H₂₀N₄O
  • Molecular Weight
    320.39
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>4 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent and selective PARP-1 and PARP-2 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    36 months
  • PubChem CID
    24958200
  • SMILES
    C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
  • InChi
    InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
  • InChi Key
    PCHKPVIQAHNQLW-CQSZACIVSA-N
  • MSDS Available
    Yes
  • Gene target
    MK-4827  
  • Gene symbol
    MVK, STYXL1, MDK, MAPKAPK3, EPCAM
  • Short name
    MK-4827
  • Alternative name
    MK-4827
Gene info
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