Canertinib (CI-1033, PD-183805)
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Catalog number1617-5
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PricePlease ask
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Size5 mg
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Alternative_nameCI-1033, PD-183805, PD 183805
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DescriptionCanertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
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CAS Number289499-45-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₅ClFN₅O₃ . 2HCl
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Molecular Weight558.86
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Cell PermeableYes
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Purity≥99%
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SolubilitiesDMSO (100 mg/ml)
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HandlingProtect from air and moisture
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Tag LineAn ErbB receptor tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping ConditionRT
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Shelf Life24months
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MDL NumberMFCD09954112
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PubChem CID156413
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SMILESC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
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InChiInChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
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InChi KeyJZZFDCXSFTVOJY-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolNDUFV3, NDUFA5, NDUFV2, NDUFA10, NDUFS1, NDUFS6, NDUFS2, NDUFV1, ENPP2, NDUFB2
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Short nameCanertinib (CI-1033, PD-183805)
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Alternative nameCanertinib (CI-1033, PD-183805)
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Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase subunit V3
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) flavoprotein 3 (10kD)
- NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
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Synonyms
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Synonyms name
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Locus
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Discovery year1994-09-07
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Entrez gene record
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Pubmed identfication
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Classification
- NADH:ubiquinone oxidoreductase supernumerary subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase subunit A5
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (13kD, B13)
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
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Synonyms
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Synonyms name
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Locus
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Discovery year1996-08-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase supernumerary subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase core subunit V2
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) flavoprotein 2 (24kD)
- NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase core subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase subunit A10
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD)
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-12-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase supernumerary subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase core subunit S1
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coenzyme Q reductase)
- NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
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Synonyms
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Synonyms name
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Locus
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Discovery year1992-04-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase core subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase subunit S6
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme Q reductase)
- NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-11-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase supernumerary subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase core subunit S2
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) Fe-S protein 2 (49kD) (NADH-coenzyme Q reductase)
- NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase core subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase core subunit V1
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) flavoprotein 1 (51kD)
- NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-07-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase core subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 2
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-08-10
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Entrez gene record
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Pubmed identfication
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNADH:ubiquinone oxidoreductase subunit B2
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Synonyms gene name
- NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 (8kD, AGGG)
- NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-11-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NADH:ubiquinone oxidoreductase supernumerary subunits
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VEGA ID