Canertinib (CI-1033, PD-183805)

  • Catalog number
    1617-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    CI-1033, PD-183805, PD 183805
  • Description
    Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules.  Canertinib alkylates a cysteine residue specific to ErbB receptors.  The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
  • CAS Number
    289499-45-2
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₄H₂₅ClFN₅O₃ . 2HCl
  • Molecular Weight
    558.86
  • Cell Permeable
    Yes
  • Purity
    ≥99%
  • Solubilities
    DMSO (100 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    An ErbB receptor tyrosine kinase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    RT
  • Shelf Life
    24months
  • MDL Number
    MFCD09954112
  • PubChem CID
    156413
  • SMILES
    C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
  • InChi
    InChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
  • InChi Key
    JZZFDCXSFTVOJY-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    NDUFV3, NDUFA5, NDUFV2, NDUFA10, NDUFS1, NDUFS6, NDUFS2, NDUFV1, ENPP2, NDUFB2
  • Short name
    Canertinib (CI-1033, PD-183805)
  • Alternative name
    Canertinib (CI-1033, PD-183805)
Gene info
  • Identity
  • Gene
  • Long gene name
    NADH:ubiquinone oxidoreductase subunit V3
  • Synonyms gene name
    • NADH dehydrogenase (ubiquinone) flavoprotein 3 (10kD)
    • NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
  • Synonyms
  • Synonyms name
  • Locus
  • Discovery year
    1994-09-07
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • NADH:ubiquinone oxidoreductase supernumerary subunits
  • VEGA ID
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    NADH:ubiquinone oxidoreductase subunit A10
  • Synonyms gene name
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD)
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1997-12-17
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • NADH:ubiquinone oxidoreductase supernumerary subunits
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
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