17-DMAG hydrochloride

• Catalog number
  1776-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; Alvespimycin
• Description
  A water-soluble analog of 17-AAG (Cat. No. 1774-1,5) that displays better stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Binds specifically to heat shock protein90 (Hsp90) in a manner similar to geldanamycin.
• CAS Number
  467214-21-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₂H₄₈N₄O₈•HCl
• Molecular Weight
  653.21
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO or H₂O ( 2 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A Hsp90 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  9852573
• PubChem CID Link
• SMILES
  CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
• InChi
  InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
• InChi Key
  DFSYBWLNYPEFJK-IHLRWNDRSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  17-DMAG   hydrochloride  
• Gene symbol
  PIRC95, PIRC91, PIRC90, SNORD115-17, IGHV3OR16-17, PIRC92, PIRC93, SNORD116-17
• Short name
  17-DMAG hydrochloride
• Alternative name
  17-DMAG hydrochloride

Gene info

• Identity
  HGNC:37599
• Gene
  PIRC95
• Long gene name
  piwi-interacting RNA cluster 95
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313935
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37595
• Gene
  PIRC91
• Long gene name
  piwi-interacting RNA cluster 91
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313900
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37594
• Gene
  PIRC90
• Long gene name
  piwi-interacting RNA cluster 90
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313798
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33036
• Gene
  SNORD115-17
• Long gene name
  small nucleolar RNA, C/D box 115-17
• Synonyms
  • HBII-52-17
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033455
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003309.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:55105
• Gene
  IGHV3OR16-17
• Long gene name
  immunoglobulin heavy variable 3/OR16-17 (non-functional)
• Synonyms
  • IGHV3/OR16-17
• Locus
  16p11.2
• Discovery year
  2020-06-26
• Entrez gene record
  390714
• Classification
  • Immunoglobulin heavy (IGH) orphons

Gene info

• Identity
  HGNC:37596
• Gene
  PIRC92
• Long gene name
  piwi-interacting RNA cluster 92
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313920
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37597
• Gene
  PIRC93
• Long gene name
  piwi-interacting RNA cluster 93
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313934
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33083
• Gene
  SNORD116-17
• Long gene name
  small nucleolar RNA, C/D box 116-17
• Synonyms
  • HBII-85-17
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033429
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003332
• Classification
  • Small nucleolar RNAs, C/D box

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