Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).
Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Is this a salt?
Is it cell-permeable?
≥98% by TLC
DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
SMER28 for activation
SMER28 to measure cellular activation