NSC 405020

• Catalog number
  2682-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3,4-Dichloro-N-(1-methylbutyl)benzamide
• Description
  NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP.
• CAS Number
  7497-07-6
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₂H₁₅Cl₂NO
• Molecular Weight
  260.16
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml) or EtOH (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent MT1-MMP inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  346721
• PubChem CID Link
• SMILES
  CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl
• InChi
  InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
• InChi Key
  ARDYECYBETXQFD-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NSC   405020  
• Short name
  NSC 405020
• Alternative name
  NSC 405020

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