p53 Antibody

• Catalog number
  bs-50458R
• Price
  Please ask
• Size
  0.1ml

• Long name
  p53 Primary Polyclonal Antibody
• Also known as
  p53 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  p53
• Specificity
  This is a highly specific antibody against p53.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Source
  Synthetic peptide
• Gene ID number
  7157
• Swiss Prot
  P04637
• Tested Applications
  WB
• Recommended dilutions
  WB (1:2,000)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  p53  
• Gene symbol
  MDM4, TP53, LNCPRESS2
• Short name
  Anti-p53
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  p53 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6974
• Gene
  MDM4
• Long gene name
  MDM4 regulator of p53
• Synonyms gene name
  • mouse double minute 4, human homolog of; p53-binding protein
  • Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
  • Mdm4 p53 binding protein homolog (mouse)
  • MDM4, p53 regulator
• Synonyms
  • MDMX
  • HDMX
• GenBank acession
  • AF007111
• Locus
  1q32.1
• Discovery year
  1997-09-05
• Entrez gene record
  4194
• Pubmed identfication
  • 9226370
  • 14660608
  • 26798135
• RefSeq identity
  • NM_002393
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000035877

Gene info

• Identity
  HGNC:11998
• Gene
  TP53
• Long gene name
  tumor protein p53
• Synonyms
  • p53
  • LFS1
• Synonyms name
  • Li-Fraumeni syndrome
• GenBank acession
  • AF307851
• Locus
  17p13.1
• Discovery year
  1986-01-01
• Entrez gene record
  7157
• Pubmed identfication
  • 6396087
  • 3456488
  • 2047879
• RefSeq identity
  • NM_000546
• VEGA ID
  OTTHUMG00000162125
• Locus Specific Databases
  • IARC TP53 Mutation Database
  • p53 UMD TP53 mutation database
  • Database of Germline p53 Mutations
  • MUTP53LOAD, Mutant p53 Loss Of Activity Database
  • LRG_321

Gene info

• Identity
  HGNC:52747
• Gene
  LNCPRESS2
• Long gene name
  lncRNA p53 regulated and ESC associated 2
• Synonyms name
  • lncRNA p53 regulated and ESC specific 2
• Locus
  4q22.1
• Discovery year
  2016-12-14
• Entrez gene record
  101929194
• Pubmed identfication
  • 27912097
• RefSeq identity
  • NR_125920
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000160917

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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