Aftin-4

• Catalog number
  2574-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4
• Description
  A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
• CAS Number
  866893-90-5
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₈N₆O
• Molecular Weight
  368.48
• Cell Permeable
  Yes
• Purity
  ≥98% by NMR
• Solubilities
  DMSO or EtOH
• Handling
  Protect from air and light
• Tag Line
  An amyloid-β42 Inducer
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• SMILES
  CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1
• InChi
  InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
• InChi Key
  YPYWONAECUVKHY-MRXNPFEDSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Aftin-4  
• Short name
  Aftin-4
• Alternative name
  Aftin-4

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